Journal of Dermatology & Dermatologic Surgery

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 24  |  Issue : 2  |  Page : 88--92

Nail manifestations in cancer chemotherapy: A cross-sectional study


Zainaba Mizaj1, Spandana P Hegde2, Guruprasad Bhat3, Vishal B Amin2, Malcolm Pinto2, Manjunath M Shenoy2 
1 Department of Dermatology, Aster Medcity, Kochi, Kerala, India
2 Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College, Mangalore, Karnataka, India
3 Department of Medical Oncology, Yenepoya Medical College, Mangalore, Karnataka, India

Correspondence Address:
Dr. Spandana P Hegde
Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College Hospital, Mangalore - 575 018, Karnataka
India

Background: Anticancer chemotherapy is associated with multisystem adverse effects. Chemotherapy can affect skin, nails, and hair and may sometimes affect the quality of life to the point of requiring discontinuation of therapy. There are many new chemotherapeutic agents, and with that, a rise in the adverse effects attributed to them. Purpose: To evaluate the frequency of nail changes occurring due to anticancer therapy. Methods: We screened 100 cancer patients admitted in the oncology ward of a tertiary care center in South India from July to September 2017. The nail changes were documented and analyzed with emphasis on developing a relationship if any with a chemotherapeutic agent. Results: Nail changes were observed in 62 (62%) cases. Breast carcinoma (20 cases) was the most common malignancy. Doxorubicin (36 cases) and cyclophosphamide (27 cases) were the most common chemotherapeutic drugs associated with nail changes. Pigmentary changes (32 cases) were the most common nail plate changes. Blue lunula (24 cases) was the most common nail bed change, occurring with cyclophosphamide/doxorubicin. Pyogenic granuloma was the only nail fold change that was noted in a patient of carcinoma of breast treated with gefitinib. Conclusion: Cancer chemotherapy may be associated with a variety of nail changes. Addressing nail changes may have the potential to improve cancer treatment patients' quality of life.


How to cite this article:
Mizaj Z, Hegde SP, Bhat G, Amin VB, Pinto M, Shenoy MM. Nail manifestations in cancer chemotherapy: A cross-sectional study.J Dermatol Dermatol Surg 2020;24:88-92


How to cite this URL:
Mizaj Z, Hegde SP, Bhat G, Amin VB, Pinto M, Shenoy MM. Nail manifestations in cancer chemotherapy: A cross-sectional study. J Dermatol Dermatol Surg [serial online] 2020 [cited 2021 Jan 25 ];24:88-92
Available from: https://www.jddsjournal.org/article.asp?issn=2352-2410;year=2020;volume=24;issue=2;spage=88;epage=92;aulast=Mizaj;type=0