Journal of Dermatology & Dermatologic Surgery

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 25  |  Issue : 1  |  Page : 37--38

Oral isotretinoin therapy and milia formation in patients with acne vulgaris: A prospective study


Fahad AlSaif1, Abdulrhman AlDakhil2, Nourah AlSyefi3, AlBatool AlAmari2, Ahmad AlAmari1, Faisal AlSaif1, Hend AlOtaibi1, Amal Balbeesi1, Nora AlBabtain1 
1 Department of Dermatology, King Saud University, College of Medicine, Riyadh, Saudi Arabia
2 Department of Dermatology, King Saud Medical City, Riyadh, Saudi Arabia
3 Department of Dermatology, King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Ahmad AlAmari
King Saud University, Riyadh
Saudi Arabia

Background: Isotretinoin (13-cis-retinoic acid) is effective in acne treatment. Isotretinoin can cause hair loss, xerosis, cheilitis, and nail changes. Milia is a reported side effect; however, little is known about the relationship between oral isotretinoin and milia formation. Purpose: The objective was to investigate milia as a potential side effect of oral isotretinoin treatment. Methods: Fifty-one patients (male/female: 21/30) aged 18–25 years with moderate-to-severe acne vulgaris were treated with a standard dose of oral isotretinoin 0.5 mg/kg/day and a cumulative dose of 120–150 mg/kg. Clinical assessments of milia were obtained at 0, 2, 4, 6, and 8 months of treatment. Results: None of the patients who received oral isotretinoin therapy developed milia. Conclusion: We found no association between oral isotretinoin at a standard dose of 0.5 mg/kg/day and milia formation in patients with moderate-to-severe acne vulgaris.


How to cite this article:
AlSaif F, AlDakhil A, AlSyefi N, AlAmari A, AlAmari A, AlSaif F, AlOtaibi H, Balbeesi A, AlBabtain N. Oral isotretinoin therapy and milia formation in patients with acne vulgaris: A prospective study.J Dermatol Dermatol Surg 2021;25:37-38


How to cite this URL:
AlSaif F, AlDakhil A, AlSyefi N, AlAmari A, AlAmari A, AlSaif F, AlOtaibi H, Balbeesi A, AlBabtain N. Oral isotretinoin therapy and milia formation in patients with acne vulgaris: A prospective study. J Dermatol Dermatol Surg [serial online] 2021 [cited 2022 May 17 ];25:37-38
Available from: https://www.jddsjournal.org/article.asp?issn=2352-2410;year=2021;volume=25;issue=1;spage=37;epage=38;aulast=AlSaif;type=0